Interaction of human cytomegalovirus with p53: possible role in coronary restenosis.

摘要: Restenosis occurs in 25-50% of patients. Within 1-6 months after coronary angioplasty, excessive injury-induced smooth muscle cell (SMC) proliferation contributes to the development restenosis; its causes remain unknown. The results this study implicate human cytomegalovirus (HCMV) and HCMV-induced abnormalities p53 function restenosis process. Almost 40% lesions, obtained by atherectomy, demonstrated increased SMC levels immunopositivity; sequencing revealed be wild type. A strong correlation was found between immunopositivity presence HCMV DNA. Moreover, IE84 protein co-immunoprecipitates with p53, transcriptional capacity is reduced IE84. Thus, may play a causal role restenosis, which at least partly mediated inhibiting suppressor effects.