Signaling through Galpha12/13 and RGS-RhoGEFs
作者： Nicole Hajicek , Barry Kreutz , Tohru Kozasa
DOI: 10.1007/978-1-4419-1111-7_4
关键词: Cell biology 、 RHOA 、 Actin 、 Heterotrimeric G protein 、 Guanine nucleotide exchange factor 、 GTPase 、 Hes3 signaling axis 、 Chemistry 、 Signal transduction 、 Cytoskeleton
摘要: The transforming heterotrimeric G proteins Gα12 and Gα13 have been implicated in the regulation of various cellular processes, such as gene transcription rearrangement actin-based cytoskeleton. Many these functions are dependent on activation monomeric GTPase RhoA. RGS-RhoGEFs, a distinct family guanine nucleotide exchange factors, which contain RGS-like domains their N-termini, serve direct links between Gα12/13 focus this chapter is molecular mechanisms that underlie regulate signaling from to RhoA via RGS-RhoGEFs. physiological significance pathway also discussed.
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