2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

作者: Alan Poland , Joyce C. Knutson

DOI: 10.1146/ANNUREV.PA.22.040182.002505

关键词: BiochemistryMechanism (biology)Aryl hydrocarbon receptor nuclear translocatorMechanism of actionStereochemistryAryl hydrocarbon receptor repressorToxicityChemistryCarcinogenAromatic hydrocarbon receptorDrug metabolism

摘要: … In rats, the total lipid content of the liver is increased: a sublethal dose of TCDD produces an increase in triglycerides and free fatty acids and a decrease in sterol esters, while a lethal …

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