Developmental Stage-Specific Responses to Ligation of CD3-Containing Complexes
DOI: 10.1007/978-1-4757-2778-4_23
关键词: Cell biology 、 CD3 、 Negative selection 、 Receptor 、 Gene 、 Ligation 、 T-cell receptor 、 Double negative 、 Chemistry 、 Somatic cell
摘要: The vast repertoire of T-cell receptor specificities is accomplished by somatic assembly V, D, and J gene segments into genes encoding the (TCR) -α -β chains. Because chances are that this partially random process does not produce a useful TCR, several selection events imposed on developing T-cells. These all controlled signals transduced through TCR-CD3 complexes. composition complex, it, responses thymocytes differ at distinct stages development. This chapter describes molecular CD3-containing complexes, as well maturation inducible upon ligation with antibodies.
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