A Pandemic Influenza H1N1 Live Vaccine Based on Modified Vaccinia Ankara Is Highly Immunogenic and Protects Mice in Active and Passive Immunizations
作者： Annett Hessel , Michael Schwendinger , Daniela Fritz , Sogue Coulibaly , Georg W. Holzer
DOI: 10.1371/JOURNAL.PONE.0012217
关键词: Neuraminidase 、 Virology 、 Virus 、 Viral Vaccine 、 Immunology 、 Vaccination 、 Modified vaccinia Ankara 、 Attenuated vaccine 、 Pandemic 、 Biology 、 Immune system
摘要: Background The development of novel influenza vaccines inducing a broad immune response is an important objective. The aim this study was to evaluate live which induce both strong humoral and cell-mediated responses against the human pandemic H1N1 virus, show protection in lethal animal challenge model.
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