Weekly diffusion-weighted imaging of normal-appearing white matter in MS.

作者: M. A. Rocca , M. Cercignani , G. Iannucci , G. Comi , M. Filippi

DOI: 10.1212/WNL.55.6.882

关键词: Multiple sclerosisLesion formationPathologyNuclear magnetic resonanceDiffusion MRIWhite matterMedicine

摘要: Article abstract To elucidate the dynamics and nature of normal-appearing white matter (NAWM) changes preceding new lesion formation in MS, authors obtained weekly diffusion-weighted images for 12 weeks from 6 patients. NAWM areas subsequently involved by enhancement had a significant increase mean diffusivity values starting before appearance ( p ranging between

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