A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer.
作者： Montreh Tavakkoli , Cy R. Wilkins , Jodi V. Mones , Michael J. Mauro
关键词: CSF secretion 、 Myeloid-derived Suppressor Cell 、 Lung cancer 、 Cancer research 、 Leukocytosis 、 Secretion 、 Non small cell 、 Suppressor 、 Neutrophil to lymphocyte ratio 、 Medicine
摘要: Leukocytosis is a common feature of malignancies. While controversial, there appears to be an association between the degree tumor-related leukocytosis and prognosis. In this paper, we provide evidence supporting untapped clinical paradigm linking G-CSF secretion induction expansion myeloid-derived suppressor cells, providing explanation for leukocytosis, elevated neutrophil-to-lymphocyte ratios prognosis in non-small cell lung cancer. Clinically validating mechanism may identify MDSCs as dynamic markers early disease progression therapeutic response, shed light onto novel avenues treatment patients with
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