Note added in proof to page 92 Endocrine Control of Metabolism in Arthropods

摘要: Since sending this paper to press a few reports of great interest have been brought the author’s notice. It was shown by Clever and Karlson (1960) that injection pure ecdysone into Chironomus larvae caused prompt characteristic changes in puffing pattern chromosome, similar those occur at pupation. Further, (1961) reported gene loci chromosomes appears 15 30 minutes after also size induced puff duration its presence correlation with dosage hormone injected. With higher they are larger last longer. In view report pupation metamorphosis different show puffs it may be presumed juvenile somehow prevents activation genes should normally up metamorphosis, during larval pupal moults. This indicates act directly on nucleus. And fact appear indicate increased metabolic activity particular chromosomal regions (Pavan, 1959) acts nuclear level activating “to bring about elaboration specific substances (ribonucleic acids, nucleotide enzymes ?) destined participate personally cytoplasmic synthesis characterise moulting” as already predicted Schneiderman Gilbert (1959). A connection is Abd-el-Wahab Sirlin (1959) who suggest decrease RNA prothoracic glands Drosophila responsible for moulting titre thereby indicating product (RNA or RNA-template) involved ecdysone.