Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
作者： Keiko Makita , John R. Falck , Jorge H. Capdevila
DOI: 10.1096/FASEBJ.10.13.8940291
关键词: Microsome 、 Chemistry 、 Oxygenase 、 Arachidonic acid 、 Epoxygenase 、 Pharmacology 、 Monooxygenase 、 Biochemistry 、 Cytochrome P450 、 Renal physiology 、 Fatty acid
摘要: As a participant of the endogenous arachidonic acid metabolic cascade, microsomal cytochrome P450 metabolizes fatty to biologically active hydroxyeicosatetraenoic and epoxyeicosatrienoic acids. Studies from several laboratories have documented powerful vasoactive properties these P450-derived eicosanoids. Associated changes in cell membrane ion permeability fluxes may provide molecular basis underlining their vasoactivity. Furthermore, role for monooxygenase renal physiology pathophysiology has been suggested by: 1) an association between activities omega/omega-1 oxygenase development hypertension spontaneously hypertensive rats, 2) relationship acquired or inherited abnormalities epoxygenase and/or regulation salt-sensitive Dahl rats. These studies significant evidence indicate that P450, addition its recognized traditio...
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