Pediatric Inflammatory Bowel Disease: from diagnosis to transition

摘要: textabstractThe inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract, comprising Crohn’s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). CD is characterized by a transmural and often granulomatous inflammation that can involve any part of the tract in discontinuous manner, while UC defined as condition causing continuous mucosal inflammation colon, without granulomas on biopsy, affecting rectum and variable extent colon continuity. The term IBD-U used for patients presenting with IBD restricted to specific features either or UC.2 Early-onset represents distinct entity differences type, disease location, behavior, gender preponderance, genetically attributable risk compared late-onset IBD. As adults, treatment early-onset aimed at inducing maintaining remission, but special considerations needed regarding optimal growth, pubertal development, transition period adult care. A better understanding between will eventually lead better understanding pathogenesis disease. One limitations of studying pediatric however relatively small number patients available for study at one institution, which requires ongoing collaborations many institutions. This thesis present six (inter)national multicenter studies, single-center pilot study and review, all focus unique clinical aspects IBD, thereby complementing body literature diagnosis of children