The Effects of Lipid-Protein Interactions on the Kinetic Parameters of Microsomal UDP-Glucuronyltransferase
作者： David Zakim , Donald A. Vessey
DOI: 10.1007/978-1-4684-2655-7_12
关键词: Acid hydrolysis 、 Glucuronic acid 、 Conjugate 、 Glucuronidation 、 Medicinal chemistry 、 Moiety 、 Microsome 、 Chemistry 、 Conjugated system 、 Molecule
摘要: The study of glucuronidation reactions began 100 years ago with the isolation a conjugate o-nitrotoluene from urine dogs. Acid hydrolysis this yielded an acidic sugar as one products. An identical was obtained on acid chloral hydrate exreted in human urine. formula reducing given correctly $$ {\left( {{\rm{CHOH}}} \right)_4}\left\{ {\begin{array}{*{20}{c}} {{\rm{CHO}}}\\ {{\rm{COOH}}} \end{array}} \right. $$ by Schmiedeberg and Meyer 1879 (Smith Williams, 1970). A wide variety organic compounds are now known to be conjugated glucuronic acid. Predominant among these aromatic molecules containing phenolic carboxylic groups which form O-ether O-ester glucuronides, respectively. Several thiols glucuronidated, N-glucuronides also have been reported (Dutton, 1966). donor moiety identified UDP-glucuronic (Dutton Storey, 1953; Dutton,
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