Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
作者： Robin M Meyers , Jordan G Bryan , James M McFarland , Barbara A Weir , Ann E Sizemore
DOI: 10.1101/160861
关键词: Genome editing 、 Dna cleavage 、 Copy number gain 、 Computational biology 、 Cancer cell lines 、 Gene 、 Subgenomic mRNA 、 Cancer cell 、 CRISPR 、 Biology
摘要: The CRISPR–Cas9 system has revolutionized gene editing both at single genes and in multiplexed loss-of-function screens, thus enabling precise genome-scale identification of genes …
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sci-hub.st 参考文章(19)
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