Conversion of angiotensin-1 to angiotensin-2 by a latent endothelial cell peptidyl dipeptidase that is not angiotensin-converting enzyme
作者： Joseph J. Lanzillo , Yamuna Dasarathy , Joanne Stevens , Barry L. Fanburg
DOI: 10.1016/S0006-291X(86)80487-9
关键词: Carboxypeptidase 、 Bradykinin 、 Lisinopril 、 Kunitz STI protease inhibitor 、 Biochemistry 、 PMSF 、 Thiorphan 、 Phosphoramidon 、 Angiotensin-converting enzyme 、 Chemistry 、 Biophysics 、 Cell biology 、 Molecular biology
摘要: Cultured bovine pulmonary artery endothelial cells contain a second peptidyl dipeptidase, distinct from angiotensin-converting enzyme, present in an inactive form associated with non-dialyzable inhibitor. Partial purification by glycine affinity chromatography separates enzyme inhibitor to yield preparation which hydrolyzes angiotensin-1, bradykinin, substance P, atriopeptin-2, enkephalin and Hip-His-Leu. This is resistant inhibition lisinopril, captopril, thiorphan, phosphoramidon, soybean trypsin inhibitor, PMSF aminopeptidase carboxypeptidase inhibitors, but inhibited EDTA.
elsevier.com
sci-hub.se 参考文章(20)
P J Del Vecchio, J W Ryan, A Chung, U S Ryan, Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities Biochemical Journal. ,vol. 186, pp. 605- 608 ,(1980) , 10.1042/BJ1860605
RA Snyder, CE Kaempfer, BU Wintroub, Chemistry of a human monocyte-derived cell line (U937): identification of the angiotensin I-converting activity as leukocyte cathepsin G Blood. ,vol. 65, pp. 176- 182 ,(1985) , 10.1182/BLOOD.V65.1.176.176
Richard L. Soffer, Biochemical regulation of blood pressure Wiley. ,(1981)
C F Reilly, D A Tewksbury, N M Schechter, J Travis, Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. Journal of Biological Chemistry. ,vol. 257, pp. 8619- 8622 ,(1982) , 10.1016/S0021-9258(18)34171-1
T Inagami, K Murakami, Purification of high molecular weight forms of renin from hog kidney. Circulation Research. ,vol. 41, pp. 11- 16 ,(1977) , 10.1161/01.RES.41.4.11
Nakahara Masao, Subunits of human plasma kininase II generated by plasma kallikrein Biochemical Pharmacology. ,vol. 27, pp. 1651- 1657 ,(1978) , 10.1016/0006-2952(78)90174-0
Elizabeth A. Thiele, Stephen M. Strittmatter, Solomon H. Snyder, Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain Biochemical and Biophysical Research Communications. ,vol. 128, pp. 317- 324 ,(1985) , 10.1016/0006-291X(85)91681-X
Frank E. Palmieri, James J. Petrelli, Patrick E. Ward, Vascular, plasma membrane aminopeptidase M. Metabolism of vasoactive peptides. Biochemical Pharmacology. ,vol. 34, pp. 2309- 2317 ,(1985) , 10.1016/0006-2952(85)90787-7
K Kumamoto, T A Stewart, A R Johnson, E G Erdös, Prolylcarboxypeptidase (angiotensinase C) in human lung and cultured cells. Journal of Clinical Investigation. ,vol. 67, pp. 210- 215 ,(1981) , 10.1172/JCI110015
D.W. Cushman, E.M. Gordon, F.L. Wang, H.S. Cheung, R. Tung, N.G. Delaney, Purification and characterization of enkephalinase, angiotensin converting enzyme, and a third peptidyldipeptidase from rat brain. Life Sciences. ,vol. 33, pp. 25- 28 ,(1983) , 10.1016/0024-3205(83)90435-6