Detector, Three-Dimensional Direct Positron Imaging Unit, and Method to Estimate the Differential of the Radiation Dose Provided to Cancer Cells and Healthy Tissues During Hadrotherapy
作者： Cristiano Galbiati
DOI:
关键词: Silicon photomultiplier 、 Xenon 、 Optics 、 Scintillation 、 Physics 、 Radiation 、 Positron 、 Detector 、 Photon 、 Argon
摘要: Disclosed is a detector for positron imaging unit, comprises hollow body with an inner cylindrical wall and outer spaced apart from the wall. The includes scintillating material, suitable to emit photons once hit by 511 keV Y-ray, one or more pairs of photo-detecting units (e.g. comprising PMTs SiPM) detecting emitted material; each unit pair being placed at opposite ends along radial direction. material has scintillation decay time τ lower than 10 ns, atomic number greater 10, high yield 8,000 photons/MeV, mixture xenon argon. An including method estimate differential dose radiation provided in subject cancer cells surrounding tissues course hadrotherapy also disclosed.
lens.org 参考文章(20)
Ronald Grazioso, Nan Zhang, Dual channel SiPM for optimal energy and fast timing ,(2007)
Alejandro Dorenbaum, Emil D. Kakkis, Daniel I. Oppenheimer, Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug ,(2008)
Mark S. Andreaco, Matthias J. Schmand, Piotr Szupryczynski, James L. Corbell, Radiation Detection With Optical Amplification ,(2012)
Adam Bernstein, Steven A. Dazeley, Robert C. Svoboda, Nathaniel Bowden, Gadolinium-doped water cerenkov-based neutron and high energy gamma-ray detector and radiation portal monitoring system ,(2010)
Katia Parodi, Thomas Bortfeld, A filtering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy. Physics in Medicine and Biology. ,vol. 51, pp. 1991- 2009 ,(2006) , 10.1088/0031-9155/51/8/003
Christine C. Wu, Michael J. MacCoss, Kathryn E. Howell, Dwight E. Matthews, John R. Yates, Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Analytical Chemistry. ,vol. 76, pp. 4951- 4959 ,(2004) , 10.1021/AC049208J
T. Alexander, D. Alton, K. Arisaka, H.O. Back, P. Beltrame, J. Benziger, G. Bonfini, A. Brigatti, J. Brodsky, L. Cadonati, F. Calaprice, A. Candela, H. Cao, P. Cavalcante, A. Chavarria, A. Chepurnov, D. Cline, A.G. Cocco, C. Condon, D. D’Angelo, S. Davini, E. De Haas, A. Derbin, G. Di Pietro, I. Dratchnev, D. Durben, A. Empl, A. Etenko, A. Fan, G. Fiorillo, K. Fomenko, F. Gabriele, C. Galbiati, S. Gazzana, C. Ghag, C. Ghiano, A. Goretti, L. Grandi, M. Gromov, M. Guan, C. Guo, G. Guray, E.V. Hungerford, Al. Ianni, An. Ianni, A. Kayunov, K. Keeter, C. Kendziora, S. Kidner, V. Kobychev, G. Koh, D. Korablev, G. Korga, E. Shields, P. Li, B. Loer, P. Lombardi, C. Love, L. Ludhova, L. Lukyanchenko, A. Lund, K. Lung, Y. Ma, I. Machulin, J. Maricic, C.J. Martoff, Y. Meng, E. Meroni, P.D. Meyers, T. Mohayai, D. Montanari, M. Montuschi, P. Mosteiro, B. Mount, V. Muratova, A. Nelson, A. Nemtzow, N. Nurakhov, M. Orsini, F. Ortica, M. Pallavicini, E. Pantic, S. Parmeggiano, R. Parsells, N. Pelliccia, L. Perasso, F. Perfetto, L. Pinsky, A. Pocar, S. Pordes, G. Ranucci, A. Razeto, A. Romani, N. Rossi, P. Saggese, R. Saldanha, C. Salvo, W. Sands, M. Seigar, D. Semenov, M. Skorokhvatov, O. Smirnov, A. Sotnikov, S. Sukhotin, Y. Suvorov, R. Tartaglia, J. Tatarowicz, G. Testera, A. Teymourian, J. Thompson, E. Unzhakov, R.B. Vogelaar, H. Wang, S. Westerdale, M. Wojcik, A. Wright, J. Xu, C. Yang, S. Zavatarelli, M. Zehfus, W. Zhong, G. Zuzel, Light Yield in DarkSide-10: A Prototype Two-Phase Argon TPC for Dark Matter Searches Astroparticle Physics. ,vol. 49, pp. 44- 51 ,(2013) , 10.1016/J.ASTROPARTPHYS.2013.08.004
P. Amaudruz, D. Bryman, L. Kurchaninov, P. Lu, C. Marshall, J.P. Martin, A. Muennich, F. Retiere, A. Sher, Simultaneous reconstruction of scintillation light and ionization charge produced by 511 keV photons in liquid xenon: Potential application to PET Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 607, pp. 668- 676 ,(2009) , 10.1016/J.NIMA.2009.06.036
Daniel B. McClatchy, Meng-Qiu Dong, Christine C. Wu, John D. Venable, John R. Yates, 15N Metabolic Labeling of Mammalian Tissue with Slow Protein Turnover Journal of Proteome Research. ,vol. 6, pp. 2005- 2010 ,(2007) , 10.1021/PR060599N
D. Acosta-Kane, R. Acciarri, O. Amaize, M. Antonello, B. Baibussinov, M. Baldo Ceolin, C.J. Ballentine, R. Bansal, L. Basgall, A. Bazarko, P. Benetti, J. Benziger, A. Burgers, F. Calaprice, E. Calligarich, M. Cambiaghi, N. Canci, F. Carbonara, M. Cassidy, F. Cavanna, S. Centro, A. Chavarria, D. Cheng, A.G. Cocco, P. Collon, F. Dalnoki-Veress, E. de Haas, F. Di Pompeo, G. Fiorillo, F. Fitch, V. Gallo, C. Galbiati, M. Gaull, S. Gazzana, L. Grandi, A. Goretti, R. Highfill, T. Highfill, T. Hohman, Al. Ianni, An. Ianni, A. LaCava, M. Laubenstein, H.Y. Lee, M. Leung, B. Loer, H.H. Loosli, B. Lyons, D. Marks, K. McCarty, G. Meng, C. Montanari, S. Mukhopadhyay, A. Nelson, O. Palamara, L. Pandola, F. Pietropaolo, T. Pivonka, A. Pocar, R. Purtschert, A. Rappoldi, G. Raselli, F. Resnati, D. Robertson, M. Roncadelli, M. Rossella, C. Rubbia, J. Ruderman, R. Saldanha, C. Schmitt, R. Scott, E. Segreto, A. Shirley, A.M. Szelc, R. Tartaglia, T. Tesileanu, S. Ventura, C. Vignoli, C. Visnjic, R. Vondrasek, A. Yushkov, Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 587, pp. 46- 51 ,(2008) , 10.1016/J.NIMA.2007.12.032