Oxazolidine Sulfur Ylides Derived from Phenylglycinol for the Specific and Highly Diastereoselective Synthesis of Aryl and Alkyl trans‐Epoxyamides
作者： Paola G Gordillo , David M Aparicio , Marcos Flores , Angel Mendoza , Laura Orea
关键词: Sulfonium 、 Alkyl 、 Oxazole 、 Stereochemistry 、 Enantioselective synthesis 、 Moiety 、 Chemistry 、 Cis–trans isomerism 、 Oxazolidine 、 Aryl
摘要: Aryl and alkyl chiral oxazolidine sulfonium salts with cis trans dispositions derived from (–)-(R)-2-phenylglycinol were demonstrated to be good excellent auxiliaries for the diastereoselective synthesis of (2R,3S)-trans-epoxyamides. Interestingly, outcome depends on stereochemistry center at C-4 position oxazole moiety. The stereoselectivities consistent even aliphatic aldehydes.
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