Structure and evolution of primate cytochrome c oxidase subunit II gene.

摘要: The sequence of cytochrome oxidase subunit II (COII) mRNA from the cynomolgus macaque has been determined. Availability a non-human primate allowed examination evolution COII gene and protein along lineage. Comparison with existing DNA sequences, combined estimates divergence derived calculations designed to compensate for multiple mutation reversion events, indicates that although rate fixation nucleotide substitutions at silent sites is somewhat lower in primates than non-primates, replacement 4-5-fold higher. data also suggest lineage not uniform, but decreased 2-2.5-fold since higher branch point, absence comparable change substitution sites. Both mRNAs differ their non-primate homologues having 3'-untranslated regions 20-25 nucleotides. Examination monkey human untranslated sequences suggests these have evolved by duplication events occurring both cases within 2-3 nucleotides following translational stop codon. are exceptional can form stable stem loop structures immediately preceding postulated site may played role facilitating mutational involved. revealed conserved significantly more hydrophobic counterparts. possible effects alterations on interaction between c discussed.