Female recruits sustaining stress fractures during military basic training demonstrate differential concentrations of circulating IGF-I system components: A preliminary study

摘要: Abstract Objective Stress fracture injuries sustained during military basic combat training (BT) are a significant problem and occur at higher rate in female recruits than male recruits. Insulin-like growth factor-I (IGF-I) is an easily measured biomarker that involved bone formation positively correlated with mineral density, especially women. This study examined the response of IGF-I system between soldiers stress (SFX, n = 13) BT who did not (NSFX, n = 49). Design Female (n = 62, 18.8 ± 0.6 yr) from 2 companies gender-integrated battalion Israeli Defense Forces participated this study. Height, weight blood draws were taken upon entry to (preBT) after four-month program (postBT). fractures diagnosed by scan. Serum was analyzed for total IGF-I, free IGF binding proteins (IGFBP)1–6, BAP, calcium, CTx, IL1β, IL6, PINP, PTH, TNFα, TRAP, 25(OH)D. Statistical differences SFX NSFX groups time points assessed RM ANOVA Fisher post-hoc (p ≤ 0.05). Results The group significantly taller had lower BMI concentrations bioavailable other biomarkers, cytokines different preBT. IGFBP-2 IGFBP-5 compared preBT In both groups, increased pre postBT Additionally, difference observed groups. demonstrated decrease (preBT: 0.58 ± 0.58 ng/mL; 0.39 ± 0.48; p ≤ 0.05) whereas increase 0.53 ± 0.37 ng/mL; postBT: 0.63 ± 0.45; p ≤ 0.05). Conclusions Our serum changes women sustaining decreased their uninjured counter parts IGF-I. These results suggest susceptibility may be related differential physical training.