Olfactometry with Mice

作者: Burton Slotnick , Diego Restrepo

DOI: 10.1002/0471142301.NS0820S33

关键词: Test chamberNeuroscienceOperant conditioningPsychologyReinforcementSensory thresholdOlfactometerCommunicationOlfactometryStimulus (physiology)Odor

摘要: A computer-controlled, multiple-channel odor generator, operant test chamber, and discrimination training procedure for mice are described. The generator allows controlled presentation of any one or combinations eight odors to an odor-sampling port that contains a liquid reinforcement delivery tube also serves detect responses. modified discrete trial conditioning provides measures both response accuracy rate during anticipation stimulus in the presence two different stimuli. Results from numerous experiments demonstrate that, with these methods, reliably rapidly acquire detection variety odor-discrimination tasks, reflects incentive motivation stimuli not associated reward.

参考文章(46)
Stuart Firestein, How the olfactory system makes sense of scents Nature. ,vol. 413, pp. 211- 218 ,(2001) , 10.1038/35093026
Markus Meister, Tobias Bonhoeffer, Tuning and topography in an odor map on the rat olfactory bulb. The Journal of Neuroscience. ,vol. 21, pp. 1351- 1360 ,(2001) , 10.1523/JNEUROSCI.21-04-01351.2001
DETLEV SCHILD, DIEGO RESTREPO, Transduction Mechanisms in Vertebrate Olfactory Receptor Cells Physiological Reviews. ,vol. 78, pp. 429- 466 ,(1998) , 10.1152/PHYSREV.1998.78.2.429
Ravinder S. Dhallan, King-Wai Yau, Karen A. Schrader, Randall R. Reed, Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. ,vol. 347, pp. 184- 187 ,(1990) , 10.1038/347184A0
James A. Dinsmoor, The effect of hunger on discriminated responding. The Journal of Abnormal and Social Psychology. ,vol. 47, pp. 67- 72 ,(1952) , 10.1037/H0061273
Matt Wachowiak, Lawrence B. Cohen, Representation of Odorants by Receptor Neuron Input to the Mouse Olfactory Bulb Neuron. ,vol. 32, pp. 723- 735 ,(2001) , 10.1016/S0896-6273(01)00506-2
Anthony Dickinson, John M. Pearce, Inhibitory interactions between appetitive and aversive stimuli. Psychological Bulletin. ,vol. 84, pp. 690- 711 ,(1977) , 10.1037/0033-2909.84.4.690
W. W. Henton, J. C. Smith, D. Tucker, Odor Discrimination in Pigeons Science. ,vol. 153, pp. 1138- 1139 ,(1966) , 10.1126/SCIENCE.153.3740.1138
Brett A. Johnson, Sabrina L. Ho, Zhe Xu, Joanne S. Yihan, Sallis Yip, Edna E. Hingco, Michael Leon, Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. The Journal of Comparative Neurology. ,vol. 449, pp. 180- 194 ,(2002) , 10.1002/CNE.10284