Coxiella burnetii in Humans and Ticks in Rural Senegal

摘要: Background Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts. Methodology/Principal Findings We investigated Q in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened the generally healthy population of two villages Sine-Saloum region. Ticks collected four regions. Seroprevalence was studied immunofluorescence, all other tested qPCR systems for detection C. Positive genotyped (multispacer typing) amplification sequencing three spacers. Strains isolated cell culture. We found that seroprevalence may be as high 24.5% (59 238 studied) Dielmo village. identified spontaneous excretion burnetii through faeces milk. Hard soft ticks (8 species) infected 0–37.6%. genotypes The previously genotype 6 most common regions only one human samples. Three strains also recovered from tick Ornithodoros sonrai. Two ticks, 35 36, first time. Conclusions/Significance should significant public health threat Humans, similar to mammals, continuously excrete