AMPK: a novel target for treating hepatic fibrosis.
作者： Zhenxing Liang , Tian Li , Shuai Jiang , Jing Xu , Wencheng Di
DOI: 10.18632/ONCOTARGET.19376
关键词: Cancer research 、 AMPK 、 Hepatic stellate cell 、 Protein kinase A 、 5'-AMP-Activated Protein Kinase 、 Hepatic fibrosis 、 Pathology 、 Pathogenesis 、 Extracellular matrix 、 Fibrosis 、 Medicine
摘要: Fibrosis is a common process of excessive extracellular matrix (ECM) accumulation following inflammatory injury. involved in the pathogenesis almost all liver diseases for which there no effective treatment. 5'-AMP-activated protein kinase (AMPK) cellular energy sensor that can ameliorate hepatic fibrogenesis. Given existing evidence, we first introduce basic background AMPK and fibrosis actions fibrosis. Second, discuss three phases potential drugs target AMPK. Third, analyze possible anti-fibrosis mechanisms other benefits on liver. Finally, summarize briefly explain current objections to targeting This review may aid clinical research AMPK, be novel drug candidate
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