Determination of Binding Constants for Cyclodextrin Complexes with Alkanols by the 1H NMR Measurements of Longitudinal Relaxation Time Using Tetramethylammonium Chloride as an Internal Reference
作者： Jalaluddin Ahmed , Tatsuyuki Yamamoto , Yoshihisa Matsui
关键词: Relaxation (NMR) 、 Tetramethylammonium chloride 、 Analytical chemistry 、 T1 measurement 、 Nuclear magnetic resonance spectroscopy 、 Cyclodextrin 、 Proton NMR 、 Longitudinal Relaxation Time 、 Binding constant 、 Chemistry
摘要: The longitudinal relaxation times (T1)of 1H NMR signals for a variety of alkanols in D2Omarkedly decreased with increasing concentrations (c)of α- and β-cyclodextrins (CD). Tetramethylammoniumchloride (TMA) used as an internal reference wasavailable evaluating effect solutionviscosity on rates R(=1/T1), since TMAshowed no appreciable interaction CD. Changes inthe ratio R alkanol protons to TMAprotons c were analyzed by the curve-fittingmethod give Ka. These Ka values agreedwell those obtained analysis changesin δ, indicating that T1 measurement is available forthe determination CD complexes. 2D ROESYspectra provided definite information molecularstructures complexes alkanols.
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sci-hub.se 参考文章(14)
FUMITOSHI HIRAYAMA, KANETO UEKAMA, HIDEOMI KOINUMA, Molecular dynamics of prostaglandin F2.ALPHA.-cyclodextrin complexes in aqueous solution. Chemical & Pharmaceutical Bulletin. ,vol. 28, pp. 1975- 1980 ,(1980) , 10.1248/CPB.28.1975
Yoshihisa Matsui, Kazuo Mochida, Binding forces contributing to the association of cyclodextrin with alcohol in an aqueous solution. Bulletin of the Chemical Society of Japan. ,vol. 52, pp. 2808- 2814 ,(1979) , 10.1246/BCSJ.52.2808
Yoshio Inoue, Takehiro Okuda, Yoshiaki Miyata, At 13C-n.m.r. study of the formation and molecular dynamics of cycloamylose inclusion-complexes with aromatic amino acids Carbohydrate Research. ,vol. 101, pp. 187- 195 ,(1982) , 10.1016/S0008-6215(00)80999-4
Koichiro Miyajima, Masahiro Sawada, Masayuki Nakagaki, Viscosity B-coefficients, apparent molar volumes, and activity coefficients for α- and γ-cyclodextrins in aqueous solutions Bulletin of the Chemical Society of Japan. ,vol. 56, pp. 3556- 3560 ,(1983) , 10.1246/BCSJ.56.3556
Yoshihisa Matsui, Shuichi Tokunaga, Internal Reference Compounds Available for the Determination of Binding Constants for Cyclodextrin Complexes by1H NMR Spectrometry Bulletin of the Chemical Society of Japan. ,vol. 69, pp. 2477- 2480 ,(1996) , 10.1246/BCSJ.69.2477
S. Cahill, S. Bulusu, Molecular complexes of explosives with cyclodextrins I. Characterization of complexes with the nitramines RDX, HMX and TNAZ in solution by1H NMR spin-lattice relaxation time measurements Magnetic Resonance in Chemistry. ,vol. 31, pp. 731- 735 ,(1993) , 10.1002/MRC.1260310808
Kenny B. Lipkowitz, Srinivasrao Raghothama, Jia An Yang, Enantioselective binding of tryptophan by .alpha.-cyclodextrin Journal of the American Chemical Society. ,vol. 114, pp. 1554- 1562 ,(1992) , 10.1021/JA00031A003
Yoshio Inoue, Yoshiaki Miyata, Formation and Molecular Dynamics of Cycloamylose Inclusion Complexes with Phenylalanine Bulletin of the Chemical Society of Japan. ,vol. 54, pp. 809- 816 ,(1981) , 10.1246/BCSJ.54.809
J. P. Behr, J. M. Lehn, Molecular dynamics of .alpha.-cyclodextrin inclusion complexes Journal of the American Chemical Society. ,vol. 98, pp. 1743- 1747 ,(1976) , 10.1021/JA00423A018
Yoshio Inoue, Yukio Katôno, Riichirô Chûjô, Molecular Dynamics of the Inclusion Complexes of Cyclohexaamylose with Some Aromatic Amino Acids and Dipeptides Bulletin of the Chemical Society of Japan. ,vol. 52, pp. 1692- 1697 ,(1979) , 10.1246/BCSJ.52.1692