Reduced Efficacy of Praziquantel Against Schistosoma mansoni Is Associated With Multiple Rounds of Mass Drug Administration.

摘要: Background. Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control in sub-Saharan Africa. The effectiveness this strategy dependent on continued high efficacy praziquantel; however, rarely monitored using appropriate statistical approaches that can detect early signs wane. Methods. We conducted a repeated cross-sectional study, examining children infected Schistosoma mansoni from 6 schools Uganda had previously received between 1 and 9 rounds MDA praziquantel. We collected up to 12 S. egg counts 414 aged 6–12 years before 25–27 days after treatment estimated individual patient reduction rates (ERRs) model explore influence covariates, including number prior rounds. Results. The average ERR among within 8 or previous (95% Bayesian credible interval [BCI], 88.23%–93.64%) was statistically significantly lower than 5 BCI, 96.13%–99.08%) round 95.51%–98.96%) MDA. estimate 5.11%, 4.55%, 16.42% 1, 5, 8–9 MDA, respectively, ERRs below 90% threshold optimal set by World Health Organization. Conclusions. The reduced higher exposure may pose threat programs. call for anthelmintic drugs used be closely monitored.