Effects of Antipsychotic Drugs and Potassium Channel Modulators on Spectral Properties of Local Field Potentials in Mouse Hippocampus and Pre-Frontal Cortex

摘要: Abstract Local field potentials (LFPs) recorded intracranially display a range of location-specific oscillatory spectra which have been related to cognitive processes. Although the mechanisms producing LFPs are not completely understood, it is likely that voltage-gated ion channels produce action and patterned discharges play significant role. It also known antipsychotic drugs (APDs) affect LFP direct inhibitory effect on potassium has reported. Additionally, implicated in pathophysiology schizophrenia, disorder for APDs primary therapies. In this study we sought to: i) better characterise effects two connectivity measures ii) examine channel modulators potential overlap with APDs. Intracranial electrodes were implanted hippocampus (HIP) pre-frontal cortex (PFC) C57BL/6J mice; power spectra, coherence phase-amplitude cross-frequency coupling measured. Drugs tested haloperidol clozapine as well (KVMs) 4-aminopyridine (4-AP), tetraethylammonium, retigabine E-4031. Both KVMs significantly reduced gamma except 4-AP, conversely increased power. Clozapine additionally between HIP PFC, while 4-AP demonstrated opposite effect. Phase-amplitude theta oscillations was by administration retigabine. These results provide previously undescribed properties demonstrate novel modulation characteristics intriguingly APD effects.