Progression of Aleutian disease in natural and experimentally induced infections of mink.

摘要: Objective To study temporal changes in amounts of viral DNA blood leukocytes over long periods, and to determine whether severity the disease is greater experimentally induced, compared with natural, infection. Animals 18 naturally 6 infected black mink; 26 brown mink. Procedure Polymerase chain reaction amplification detect counter-immune electrophoresis serum antibody were performed at regular intervals. Results In mink, initially high, but after appearance antibody, fluctuated and, some instances, was undetectable. other small infrequently detected during course Amounts late stages correlated renal lesions mink had more severe associated smaller DNA. Severity not enhanced inoculated Conclusions After infection, leukocyte present large amounts, but, most decreases markedly association antibody. There no difference progression between or naturally. Transmission may be by use contaminated toenail clippers for collection.