Neuroleptic monitoring : relation between antipsychotic efficiency and radioreceptor assay of serum haloperidol

摘要: Objective : We report preliminary results from use of a radioreceptor assay (RRA) to measure serum haloperidol levels and their relation clinical response adverse effects in 19 psychotic patients with positive symptoms treated haloperidol. Methods Blood samples were taken on Days 7, 14 21. Clinical evaluation was based the PANSS, UKU scales. The D2 antidopaminergic RRA used levels. Results Our show correlation between psychosis assessed by scores PANSS drug level measured concentrations. observed relationship made it possible establish therapeutic range equivalents 15-30 ng/ml -1 . This contained no non-responders. Analysis each item subscale concentration suggested that there specific symptom closely related during first 15 days treatment. In third week, however, certain connected concentration. Conclusion From these results, can be concluded antipsychotic activity blockade dopamine receptors. future would desirable monitor neuroleptic treatment this way. study also showed did not correct any component stage but so at later times.