Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery doppler waveforms

摘要: The abnormal umbilical artery Doppler waveform represented by absent end-diastolic flow velocity (AEDFV) identifies a group of preterm small-for-gestational age fetuses that are at high risk perinatal death due to chronic fetal hypoxia. placental ischaemia results from inadequate trophoblast invasion spiral arterioles leads an assumption villous hypoxia, though alternative explanation is the placenta fails adequately transfer oxygen fetus intervillous space. Because transport takes place within terminal villi, we undertook first detailed studies ultrastructure structure and immunohistochemistry in order determine likely origin hypoxia this condition. Terminal villi were examined ultrastructurally using transmission electron microscopy immunohistochemical localization matrix molecules (laminin collagens I, III IV) marker cell proliferation (MIB-1), 16 pregnancies with AEDFV [deemed have intrauterine growth restriction (IUGR)] gestation age-matched controls. IUGR cases smaller diameter ( P