Fabrication of triple-layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation
作者： Hao-Yang Mi , Xin Jing , Emily Yu , Jason McNulty , Xiang-Fang Peng
DOI: 10.1016/J.MATLET.2015.08.119
关键词: Scaffold 、 Protein filament 、 Materials science 、 SILK 、 Layer (electronics) 、 Fabrication 、 Thermoplastic polyurethane 、 Composite material 、 Electrospinning 、 Ultimate tensile strength
摘要: Abstract Triple-layered small diameter vascular scaffolds, which consisted of thermoplastic polyurethane (TPU) and silk, were fabricated in this study for the first time by combining electrospinning, braiding, thermally induced phase separation methods. These novel possess three layers different structures (nanofibrous inner layer, woven silk filament middle porous outer layer), can mimic structure native blood vessels. The scaffolds have a desirable toe region tensile tests sufficient suture retention burst pressure graft applications. Endothelial cell culture showed that layer could form on surface scaffold with high viability favorable morphology.
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