In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system.

摘要: The array of specialized neuronal and glial cell types that characterize the adult central nervous system originates from neuroepithelial proliferating precursor cells. transition cells to lineages is accompanied by rapid global changes in gene expression coordination with epigenetic modifications at level chromatin structure. A number genetic studies have begun reveal how deregulation results neurodevelopmental disorders such as mental retardation, autism, Rubinstein-Taybi syndrome Rett syndrome. In this review we focus on role methyl-CpG binding protein 2 (MeCP2) during development its involvement First, present recent findings indicate a previously unconsidered Next, discuss evidence MeCP2 deficiency or loss function aberrant leading We also MeCP2's repressor activator different target genes, including microRNAs, development. Finally, address signaling pathways regulate both post-transcriptional post-translational level, mutations may result lack responsiveness environmental signals.