作者: Ankush Banerjee , Modhu Sudan Maji
关键词: Annulation 、 Catalysis 、 Chemistry 、 Reagent 、 Combinatorial chemistry 、 Cascade reaction 、 Reaction intermediate 、 Indole test 、 Brønsted–Lowry acid–base theory 、 Pyrrole
摘要: A Bronsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue eliminated by choosing appropriate carbonyls. readily available cheap bottle reagent was used as catalyst. This protocol also applicable synthesis of densely α-(3-pyrrolyl) ketones. detailed mechanistic study confirmed involvement enolether a reaction intermediate. Several postsynthetic modifications along with easy access β-carboline, tryptamines, tryptophols, spiro-indolenine proclaim synthetic utility this powerful building block. On basis concept, carbazoles were constructed cascade annulation strategy.