Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria
作者： Jian-Ying Wang , Richard M. Burger , Karl Drlica
DOI: 10.1128/AAC.42.3.709
关键词: Superoxide dismutase 、 Enzyme 、 Superoxide 、 Biochemistry 、 Catalase-peroxidase 、 Biology 、 Mycobacterium smegmatis 、 Enzyme complex 、 Isoniazid 、 Plumbagin
摘要: Isoniazid (INH) activation in vitro is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction O2 to form an oxyferrous enzyme complex. Since this complex could also directly via superoxide, intracellular might be responsive superoxide concentration. When Mycobacterium smegmatis carrying M. bovis katG gene was treated nontoxic levels plumbagin, a generator bacteriostatic activity INH increased unless plasmid-borne dismutase present. Thus, endogenous probably contributes INH.
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