A neurogenic timing factor in control of the ovulatory discharge of luteinizing hormone in the cyclic rat.

摘要: INTRODUCTION It was reported in the preceding paper (Sawyer, Everett and Markee, 1949) that a neural factor is involved release of LH2 from female rat hypophysis response to estrogen treatment, thus extending “spontaneously” ovulating species principles whichhad been previously disclosed rabbit (Markee, et al., 1946, 1948; Sawyer, 1947, 1948). Although estradiol benzoate injected on fourth day pregnancy regularly induces ovulation within 48 hours (Everett, 1947), this effect could be prevented most cases by Dibenamine or atropine, administered as late 20 after estrogen. proposed modifies threshold activation ofan hypothalamic center, certain afferentpathways leading “center,” chief difference between lies particular afferent pathways concerned.