Methods for the Preparation of Optically Active Chiral Compounds

摘要: The biological activity of chiral compounds is markedly affected by their chirality and there a growing demand for the synthesis such molecules in enantiopure form order to limit and/or suppress adverse effects deriving from use racemic mixtures. This tendency agreement with objectives “green chemistry”, that gives central emphasis protection human environmental health through design new chemicals processes. Among different methods preparation optically active compounds, resolutions can be improved addition racemization step recycle unwanted enantiomer or using automated chromatographic methodologies. In stoichiometric asymmetric substrates auxiliary groups allows control stereochemical outcome several reactions intramolecular transfer chirality. Although these methodologies continue widely employed, catalysis has emerged as more sustainable option some processes have been yet applied at industrial level.