The Role of Cold Insoluble Globulin (Plasma Fibronectin) in Cell Adhesion In Vitro

摘要: It is appropriate that a volume on cell growth factors include chapter in adhesion. Throughout the early phases during which culture techniques were developed, cells almost always grown attached to extracellular substrata and rarely suspension. The role of adhesion control became particular interest following observation transformed variants could be selected from populations by soft agar (Mac Pherson Montagnier, 1964). Subsequently, it was demonstrated normal required attachment substratum order grow, property called “anchorage dependence” (Stoker et al, 1968). To this day, best vitro correlate malignant transformation still loss (e.g. Kahn Shin, 1979). Lymphocytes are only whose apparently anchorage independent these vessels normally very tenuous.