Antiplatelet effects of protopine isolated from tubers
作者： Feng-Nien Ko , Tian-Shung Wu , Sheng-Teh Lu , Yang-Chang Wu , Tur-Fu Huang
DOI: 10.1016/0049-3848(89)90170-9
关键词: Chemistry 、 Biochemistry 、 Calcium in biology 、 Protopine 、 Corydalis 、 Arachidonic acid 、 Ionophore 、 Thromboxane 、 Thrombin 、 Pharmacology 、 Platelet 、 Hematology
摘要: Abstract Protopine inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, PAF, collagen ionophore A23187. Although platelet caused thrombin was not protopine (100 ug/ml), reaction partially suppressed. In platelet-rich plasma, also PAF collagen. The thromboxane B 2 formation washed collagen, A23187 suppressed protopine. intracellular calcium increase acid in quin-2/AM loaded platelets. presence indomethacin, completely protopine, inhibited. phosphoinositides breakdown but that affected significantly. did cause elevation cyclic AMP level It is concluded antiplatelet effects due to inhibition on then lead decrease concentration.
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sci-hub.se 参考文章(19)
E M Huang, T C Detwiler, The effects of lithium on platelet phosphoinositide metabolism. Biochemical Journal. ,vol. 236, pp. 895- 901 ,(1986) , 10.1042/BJ2360895
M M Billah, E G Lapetina, Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. Journal of Biological Chemistry. ,vol. 257, pp. 12705- 12708 ,(1982) , 10.1016/S0021-9258(18)33568-3
Sheng-Teh Lu, Chun-Nan Lin, Tien-Shung Wu, Studies on the Alkaloids of Formosan Corydalis Species: Part III. Alkaloids of Corydalis Tashiroi Makino Journal of The Chinese Chemical Society. ,vol. 19, pp. 41- 44 ,(1972) , 10.1002/JCCS.197200005
M. Johan Broekman, Jean W. Ward, Aaron J. Marcus, Phospholipid Metabolism in Stimulated Human Platelets: CHANGES IN PHOSPHATIDYLINOSITOL, PHOSPHATIDIC ACID, AND LYSOPHOSPHOLIPIDS Journal of Clinical Investigation. ,vol. 66, pp. 275- 283 ,(1980) , 10.1172/JCI109854
E. G. Lapetina, S. P. Watson, P. Cuatrecasas, myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 7431- 7435 ,(1984) , 10.1073/PNAS.81.23.7431
T. J. Rink, A. Sanchez, T. J. Hallam, Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets Nature. ,vol. 305, pp. 317- 319 ,(1983) , 10.1038/305317A0
Edward J. Hornby, Ian F. Skidmore, Evidence that prostaglandin endoperoxides can induce platelet aggregation in the absence of thromboxane A2 production Biochemical Pharmacology. ,vol. 31, pp. 1158- 1160 ,(1982) , 10.1016/0006-2952(82)90359-8
Y Nishizuka, Turnover of inositol phospholipids and signal transduction Science. ,vol. 225, pp. 1365- 1370 ,(1984) , 10.1126/SCIENCE.6147898
Craig B. Neylon, Roger J. Summers, Stimulation of α1-adrenoceptors in rat kidney mediates increased inositol phospholipid hydrolysis British Journal of Pharmacology. ,vol. 91, pp. 367- 376 ,(1987) , 10.1111/J.1476-5381.1987.TB10291.X
Hideaki Matsuda, Hidemi Shiomoto, Shunsuke Naruto, Kensuke Namba, Michinori Kubo, Anti-thrombic action of methanol extract and alkaloidal components from Corydalis tuber. Planta Medica. ,vol. 54, pp. 27- 33 ,(1988) , 10.1055/S-2006-962324