Lymphocytotoxic antibody in inflammatory bowel disease. A family study.
作者： Stanley J. Korsmeyer , Ralph C. Williams , I. Dodd Wilson , Robert G. Strickland
DOI: 10.1056/NEJM197511272932203
关键词: Proband 、 Inflammatory bowel disease 、 Disease 、 Immunology 、 Lymphocytotoxic antibody 、 Family member 、 Donor Lymphocytes 、 Antibody 、 Medicine
摘要: Abstract The prevalence of lymphocytotoxic antibody in inflammatory bowel disease is 40 per cent. Twenty-seven 90 relatives 23 probands with the (30 cent) demonstrated antibody, as contrasted only three 69 control family members (4 (P<0.0001). Decreased lymphocytotoxicity against lymphocytes from patients compared to normal donor previously serum was also observed serums probands. Nineteen 48 household contacts (40 were positive for whereas eight 42 nonhousehold (19 it (P < 0.05). Eight 16 spouses (50 showed antibody. increased and its occurrence mainly (consanguineous non-consanguineous) may indicate exposure their member...
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