作者: M. M. Frank
DOI: 10.1007/978-3-642-83755-5_26
关键词: Membrane 、 Chemistry 、 Cell biology 、 Classical complement pathway 、 Cytoplasm 、 Complement system 、 Complement membrane attack complex 、 Cell membrane 、 Viral envelope 、 Bacterial outer membrane
摘要: There are three principal mechanisms by which complement controls invasion microorganisms(Frank 1988). Binding of to the surface an organism leads sequential activation components C5 C9 with formation a complex these proteins (the membrane attack complex). The has hydrophobic and inserts into cell lipid microorganism. This cylinder like structure hydrophilic central axis destabilizes osmotic regulation causing death. In case gram negative organisms, insertion C5b-9 appears occur principally in outer membrane. precise for dissolution inner or cytoplasmic is unknown ultimate cause death organisms unknown(Taylor Enveloped viruses may have typical lesions formed their membranes upon leading loss viral integrity(Cooper 1986). Parasites such as, promastigotes Leishmania Schistosoma mansoni cercaria undergo direct dissolution(Joiner