Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.

摘要: The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together intermediates at defined locations within cells. In heart, participates in fine control excitation–contraction coupling, hence, any disregulation this cascade lead cardiac disease. Due ubiquitous nature pathway, general inhibitors proteins such as PKA, EPAC and PDEs would non-specifically universally, increasing likelihood serious ‘off target’ effects. Recent advances discovery peptides small molecules disrupt interactions underpin targeting are described discussed.