Structure Elucidation of Sch 20561, a Cyclic Dehydropeptide Lactone - a Major Component of W-10 Antifungal Antibiotic
作者： ADRIANO AFONSO , FRANK HON , RAY BRAMBILLA , MOHINDAR S. PUAR
DOI: 10.7164/ANTIBIOTICS.52.398
关键词: Cyclic peptide 、 Bacteria 、 Organic chemistry 、 Fermentation 、 Stereochemistry 、 Antifungal antibiotic 、 Aglycone 、 Chemical decomposition 、 Chemical transformation 、 Chemistry 、 Lactone
摘要: Antibiotic W-10 is a fermentation complex produced by the bacterium Aeromonas sp. W-10. The cyclic dehydropeptide lactones Sch 20562 (1) and 20561 (2) are major components of this biological interest in view their unique structural features potent antifungal activity. chemical degradation studies that were utilized assignment structure 2 for described here. determination made use ozonolytic cleavage units to form fragments sequenced mass spectrometry. lactone was found be aglycone these two natural products correlated transformation involving deglucosidation 1 2.
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