Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy

摘要: Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate effect ammonia using 13N‑labeled positron emission tomography (PET) humans. A total 20 patients were enrolled study, with mean age 59.5 years, comprising 16 males four females. Of these patients, eight underwent right 12 left CEA. rate stenosis was between 50‑69% six 70‑99% 11 at 100% (thrombosis) three measured by computerised digital subtraction angiography prior (137 MBq) PET scanning performed subsequent surgery each patient. first scan 1 day CEA, while second 1‑4 weeks Following injection ammonia, static acquired 10 min. region interest (ROI), covering hemisphere, selected uptake ROI determined ipsilateral contralateral hemispheres. No hyperperfusion syndrome observed significant change hemisphere hemispheres (ratio =0.98; P>0.01) or =1.09; Ammonia significantly reduced 23.2 23.5%, respectively, Using severe stenosis, demonstrated that reduced.