Aryl Hydrocarbon Receptors in Osteoclast Lineage Cells Are a Negative Regulator of Bone Mass

摘要: Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as key contributor to bone metabolism following studies systemic AhR knockout (KO) or transgenic mice, the cellular molecular mechanism(s) this process remain unclear. In study, we explored function of using AhRRANKΔOc/ΔOc (RANKCre/+;AhRflox/flox) mice. We observed enhanced mass together with decreased resorption both male female 12 24-week-old Control mice treated 3-methylcholanthrene (3MC), an agonist, exhibited increased resorption, whereas AhRCtskΔOc/ΔOc (CtskCre/+;AhRflox/flox) injected 3MC appeared have normal phenotype. vitro, marrow-derived macrophages (BMDMs) from impaired osteoclastogenesis repressed differentiation downregulated expression B lymphocyte-induced maturation protein 1 (Blimp1), cytochrome P450 genes Cyp1b1 Cyp1a2. Collectively, our results not only demonstrated that osteoclast lineage cells is physiologically relevant regulator but also highlighted need for further on skeletal actions inhibitors commonly associated diseases, especially diseases linked environmental pollutants known induce loss.