Discrepancy in the regulatory effects of sodium and guanine nucleotides on adrenaline and clonidine binding to α2-adrenoceptors in human fat cell membranes
作者： José-Luis Gonzalez , Christian Carpene , Michel Berlan , Max Lafonta
DOI: 10.1016/0014-2999(81)90517-3
关键词: Adrenergic receptor 、 Sodium 、 Yohimbine 、 Endocrinology 、 Agonist 、 Cyclase 、 Guanine 、 Internal medicine 、 Chemistry 、 Clonidine 、 Adenylate kinase
摘要: Abstract Guanine nucleotides and sodium were found to reduce the affinity of adrenaline for α 2 -adrenoceptor sites labelled by [ 3 H]yohimbine in human fat cell membranes. Surprisingly, negative regulation these agents was far weaker when clonidine, -agonist prototype used. The results are discussed relation or lack adenylate cyclase inhibition promoted clonidine indicate that formation lower state α-receptor is essential -adrenoceptor-mediated inhibition.
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