Risk factors for genital ulcerations in Kenyan sex workers. The role of human immunodeficiency virus type 1 infection.

摘要: Background and objectives Genital ulcer disease (GUD) is a major risk factor for human immunodeficiency virus (HIV) transmission. Cross-sectional studies have suggested that HIV infection may itself predispose to genital ulceration (GU). Goal To prospectively study the effects of type 1 (HIV-1) behavioral variables on GU incidence. Methods A cohort 302 Kenyan female sex-workers was established in April 1991. Women were scheduled assessment every 2 weeks, bloods collected 6 months serology, rapid plasma reagin (RPR) CD4 counts. Logistic regression used factors incident ulcers. Results 189 women (62.5%) had at least one over 24.3 +/- 15.3 months. incidence higher seropositive than initially seronegative (82% vs. 48%; odds ratio [OR]) = 4.33; P Conclusion sex workers independently affected by HIV-1 serostatus, degree immunosuppression, oral contraceptive use.