Anti-toxoplasmosis drugs
作者： Derouin F
DOI:
关键词: Pharmacology 、 Drug 、 Apicoplast 、 Toxoplasmosis 、 Atovaquone 、 Intestinal absorption 、 Medicine 、 Folate Inhibitors 、 Antibiotics 、 Toxoplasma gondii
摘要: The drugs most commonly used for treatment of toxoplasmosis combine folate inhibitors that frequently cause undesirable side effects. There is an urgent need new or drug combinations are able to eradicate the tissue cysts responsible relapses, particularly patients intolerant inhibitors. Although promising its activity against cysts, atovaquone still limited by variable intestinal absorption. recent demonstration apicoplast Toxoplasma gondii could be a possible unique target antibiotics such as macrolides and fluoroquinolones represented important breakthrough in this area.
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