Improving the Design of Future PCI Trials for Stable Coronary Artery Disease: JACC State-of-the-Art Review

摘要: The role of percutaneous coronary interventions in addition to medical therapy for patients with stable artery disease continues be debated routine clinical practice, despite more than 2 decades randomized controlled trials. residual uncertainty arises from particular challenges facing revascularization Which endpoint do doctors care about, and which about? participants should enrolled? What background we use? When is placebo control relevant? In this paper, discuss how these questions can approached examine the merits disadvantages possible options. Engaging multiple stakeholders, including patients, researchers, regulators, funders, ensure design elements are methodologically valid clinically meaningful an aspirational goal development future