Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma
作者： Alison J. Moskowitz , Joachim Yahalom , Tarun Kewalramani , Jocelyn C. Maragulia , Jill M. Vanak
DOI: 10.1182/BLOOD-2010-05-282756
关键词: Etoposide 、 Refractory Hodgkin Lymphoma 、 Hematopoietic stem cell transplantation 、 Oncology 、 Internal medicine 、 Chemoradiotherapy 、 Salvage therapy 、 Transplantation Conditioning 、 Surgery 、 Medicine 、 Autologous stem-cell transplantation 、 Transplantation
摘要: To identify prognostic factors for patients transplanted relapsed or refractory Hodgkin lymphoma we carried out a combined analysis of followed prospectively on 3 consecutive protocols at Memorial Sloan-Kettering Cancer Center. One hundred fifty-three with chemosensitive disease after ICE (ifosfamide, carboplatin, and etoposide)–based salvage therapy (ST) proceeded to high-dose chemoradiotherapy by autologous stem cell transplantation (ASCT). Patients were evaluated computed tomography functional imaging (gallium fluorodeoxyglucose-positron emission tomography) prior ST again before ASCT. Functional status ASCT was the only factor significant event-free survival (EFS) overall multivariate clearly identifies poor risk (5-year EFS 31% 75% FI-positive negative respectively). Administration involved-field radiotherapy marginally (P = .055). Studies evaluating novel STs, conditioning regimens, post-ASCT maintenance, allogeneic are warranted who fail normalize pre-ASCT imaging.
ashpublications.org
bloodjournal.org
elsevier.com参考文章(14)
Elias Jabbour, Chitra Hosing, Gregory Ayers, Rodolfo Nunez, Paolo Anderlini, Barbara Pro, Issa Khouri, Anas Younes, Fredrick Hagemeister, Larry Kwak, Luis Fayad, Pretransplant positive positron emission tomography/gallium scans predict poor outcome in patients with recurrent/refractory Hodgkin lymphoma. Cancer. ,vol. 109, pp. 2481- 2489 ,(2007) , 10.1002/CNCR.22714
Andrea Gallamini, Martin Hutchings, Luigi Rigacci, Lena Specht, Francesco Merli, Mads Hansen, Caterina Patti, Annika Loft, Francesco Di Raimondo, Francesco D'Amore, Alberto Biggi, Umberto Vitolo, Caterina Stelitano, Rosario Sancetta, Livio Trentin, Stefano Luminari, Emilio Iannitto, Simonetta Viviani, Ivana Pierri, Alessandro Levis, Early Interim 2-[18F]Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Is Prognostically Superior to International Prognostic Score in Advanced-Stage Hodgkin's Lymphoma: A Report From a Joint Italian-Danish Study Journal of Clinical Oncology. ,vol. 25, pp. 3746- 3752 ,(2007) , 10.1200/JCO.2007.11.6525
Roberto Crocchiolo, Carla Canevari, Andrea Assanelli, Francesca Lunghi, Michela Tassara, Maria Lupo Stanghellini, Daniela Clerici, Claudio Landoni, Paolo Servida, Massimo Bernardi, Jacopo Peccatori, Andres Ferreri, Luigi Gianolli, Claudio Bordignon, Federico Caligaris-Cappio, Fabio Ciceri, Ferruccio Fazio, Pre-transplant 18FDG-PET predicts outcome in lymphoma patients treated with high-dose sequential chemotherapy followed by autologous stem cell transplantation. Leukemia & Lymphoma. ,vol. 49, pp. 727- 733 ,(2008) , 10.1080/10428190701885545
Bart W. Schot, Josée M. Zijlstra, Wim J. Sluiter, Gustaaf W. van Imhoff, Jan Pruim, Willem Vaalburg, Edo Vellenga, Early FDG-PET assessment in combination with clinical risk scores determines prognosis in recurring lymphoma Blood. ,vol. 109, pp. 486- 491 ,(2007) , 10.1182/BLOOD-2005-11-006957
Craig H. Moskowitz, Joachim Yahalom, Andrew D. Zelenetz, Zhigang Zhang, Daniel Filippa, Julie Teruya-Feldstein, Tarun Kewalramani, Alison J. Moskowitz, Robert David Rice, Jocelyn Maragulia, Jill Vanak, Tanya Trippett, Paul Hamlin, Steven Horowitz, Ariela Noy, Owen A. O’Connor, Carol Portlock, David Straus, Stephen D. Nimer, High-dose chemo-radiotherapy for relapsed or refractory Hodgkin lymphoma and the significance of pre-transplant functional imaging. British Journal of Haematology. ,vol. 148, pp. 890- 897 ,(2010) , 10.1111/J.1365-2141.2009.08037.X
Karoline Spaepen, Sigrid Stroobants, Patrick Dupont, Peter Vandenberghe, Johan Maertens, Guy Bormans, José Thomas, Jan Balzarini, Christine De Wolf-Peeters, Luc Mortelmans, Gregor Verhoef, Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation Blood. ,vol. 102, pp. 53- 59 ,(2003) , 10.1182/BLOOD-2002-12-3842
Craig H. Moskowitz, Stephen D. Nimer, Andrew D. Zelenetz, Tania Trippett, Eric E. Hedrick, Daniel A. Filippa, Diane Louie, Maria Gonzales, Janine Walits, Nancy Coady-Lyons, Jing Qin, Richard Frank, Joseph R. Bertino, Andre Goy, Ariela Noy, James P. O'Brien, David Straus, Carol S. Portlock, Joachim Yahalom, A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model Blood. ,vol. 97, pp. 616- 623 ,(2001) , 10.1182/BLOOD.V97.3.616
Karyn A. Goodman, Elyn Riedel, Victoria Serrano, Subhash Gulati, Craig H. Moskowitz, Joachim Yahalom, Long-Term Effects of High-Dose Chemotherapy and Radiation for Relapsed and Refractory Hodgkin's Lymphoma Journal of Clinical Oncology. ,vol. 26, pp. 5240- 5247 ,(2008) , 10.1200/JCO.2007.15.5507
Martin Hutchings, Annika Loft, Mads Hansen, Lars Møller Pedersen, Thora Buhl, Jesper Jurlander, Simon Buus, Susanne Keiding, Francesco D'Amore, Anne-Marie Boesen, Anne Kiil Berthelsen, Lena Specht, FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma Blood. ,vol. 107, pp. 52- 59 ,(2006) , 10.1182/BLOOD-2005-06-2252
D.C. Linch, A.H. Goldstone, A. McMillan, R. Chopra, G. Vaughan Hudson, D. Winfield, B. Hancock, D. Moir, D. Milligan, Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial The Lancet. ,vol. 341, pp. 1051- 1054 ,(1993) , 10.1016/0140-6736(93)92411-L