Calcium and Proteases

摘要: Calcium ions (Ca2+) are key second messengers in a variety of eukaryotic cell signaling pathways, and they function the regulation diverse cellular processes. While it has become clear that Ca2+ stimulates many processes, such as muscle contraction, proliferation, gene expression, secretion hormones neurotransmitters, exocytosis, chemotaxis, also been realized is very toxic. Thus, free intracellular concentration ([Ca2+]i) must be highly regulated to achieve proper balance between Ca2+-mediated death. The importance calcium homeostasis appreciated when one considers number subcellular compartments regulating [Ca2+]i well diversity process controlled by Ca2+-signaling pathways. Each these can targeted chemicals or drugs, which elicit an imbalance resulting toxicity manifested impaired This chapter provides basic understanding messenger system, Ca2+-activated proteases, calpains PLA2, their injury.