Cardiovascular Health, Erectile Dysfunction, and Testosterone Replacement: Controversies and Correlations.
作者： Fuad F. Elkhoury , Amarnath Rambhatla , Jesse N. Mills , Jacob Rajfer
DOI: 10.1016/J.UROLOGY.2017.07.030
关键词: Endocrinology 、 Testosterone (patch) 、 Internal medicine 、 Hormone replacement therapy (female-to-male) 、 Cardiovascular health 、 Risk factor 、 Intensive care medicine 、 Erectile dysfunction 、 Disease 、 Medicine 、 Testosterone replacement 、 Low serum testosterone
摘要: Erectile dysfunction and cardiovascular disease share a similar underlying pathophysiology, low serum testosterone, known as hypogonadism, is significant player in both conditions. Hypogonadism risk factor for events worsened mortality, thus influencing physicians to recommend testosterone replacement hypogonadal men. However, at least 4 recent reports suggest that may worsen risk, heightening hesitancy the medical community treat patients with hypogonadism testosterone. This review highlights triad of disease, erectile dysfunction, therapy provides physician some guiding principles navigating these concerns.
sci-hub.se 参考文章(50)
Maple M. Fung, Richele Bettencourt, Elizabeth Barrett-Connor, Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. Journal of the American College of Cardiology. ,vol. 43, pp. 1405- 1411 ,(2004) , 10.1016/J.JACC.2003.11.041
Giuseppe Caminiti, Maurizio Volterrani, Ferdinando Iellamo, Giuseppe Marazzi, Rosalba Massaro, Marco Miceli, Caterina Mammi, Massimo Piepoli, Massimo Fini, Giuseppe M.C. Rosano, Effect of Long-Acting Testosterone Treatment on Functional Exercise Capacity, Skeletal Muscle Performance, Insulin Resistance, and Baroreflex Sensitivity in Elderly Patients With Chronic Heart Failure Journal of the American College of Cardiology. ,vol. 54, pp. 919- 927 ,(2009) , 10.1016/J.JACC.2009.04.078
Trinity J. Bivalacqua, Mustafa F. Usta, Hunter C. Champion, Philip J. Kadowitz, Wayne J. G. Hellstrom, Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. Journal of Andrology. ,vol. 24, ,(2003) , 10.1002/J.1939-4640.2003.TB02743.X
Katherine García‐Malpartida, Rosario Mármol, Ana Jover, Manuel J. Gómez‐Martínez, Eva Solá‐Izquierdo, Victor M. Victor, Milagros Rocha, Darío Sanmiguel, Antonio Hernández‐Mijares, Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Type 2 Diabetic Patients with No Known Macrovascular Complications The Journal of Sexual Medicine. ,vol. 8, pp. 2606- 2616 ,(2011) , 10.1111/J.1743-6109.2011.02365.X
Geoffrey Hackett, Nigel Cole, Mithun Bhartia, David Kennedy, Jessie Raju, Peter Wilkinson, Testosterone Replacement Therapy with Long-Acting Testosterone Undecanoate Improves Sexual Function and Quality-of-Life Parameters vs. Placebo in a Population of Men with Type 2 Diabetes The Journal of Sexual Medicine. ,vol. 10, pp. 1612- 1627 ,(2013) , 10.1111/JSM.12146
Erik J. Giltay, Yuliya A. Tishova, George J. Mskhalaya, Louis J.G. Gooren, Farid Saad, Svetlana Y. Kalinchenko, Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome The Journal of Sexual Medicine. ,vol. 7, pp. 2572- 2582 ,(2010) , 10.1111/J.1743-6109.2010.01859.X
Culley C. Carson III, Giuseppe Rosano, Exogenous Testosterone, Cardiovascular Events, and Cardiovascular Risk Factors in Elderly Men: A Review of Trial Data The Journal of Sexual Medicine. ,vol. 9, pp. 54- 67 ,(2012) , 10.1111/J.1743-6109.2011.02337.X
Michael Zitzmann, Andreas Mattern, Jens Hanisch, Louis Gooren, Hugh Jones, Mario Maggi, None, IPASS: A Study on the Tolerability and Effectiveness of Injectable Testosterone Undecanoate for the Treatment of Male Hypogonadism in a Worldwide Sample of 1,438 Men The Journal of Sexual Medicine. ,vol. 10, pp. 579- 588 ,(2013) , 10.1111/J.1743-6109.2012.02853.X
Rishi Sharma, Olurinde A. Oni, Kamal Gupta, Guoqing Chen, Mukut Sharma, Buddhadeb Dawn, Ram Sharma, Deepak Parashara, Virginia J. Savin, John A. Ambrose, Rajat S. Barua, Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. European Heart Journal. ,vol. 36, pp. 2706- 2715 ,(2015) , 10.1093/EURHEARTJ/EHV346
Henry A Feldman, Catherine B Johannes, Carol A Derby, Ken P Kleinman, Beth A Mohr, Andre B Araujo, John B McKinlay, None, Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Preventive Medicine. ,vol. 30, pp. 328- 338 ,(2000) , 10.1006/PMED.2000.0643