Electrochemical Immunosensor for Carcinoembryonic Antigen Detection Based on Mo–Mn3O4/MWCNTs/Chits Nanocomposite Modified ITO Electrode
作者： Wen-Ting Li , Yu Wang , Fen-Fang Deng , Li-Li Liu , Hai-Jun Nan
DOI: 10.1142/S1793292015501118
关键词: Materials science 、 Electrode 、 Linear range 、 Detection limit 、 Oxide 、 Clinical diagnosis 、 Electrochemistry 、 Nuclear chemistry 、 Carcinoembryonic antigen 、 Nanotechnology 、 Nanocomposite
摘要: A novel electrochemical immunosensor for determination of carcinoembryonic antigen (CEA) in human serum was fabricated by depositing Mo–Mn3O4/MWCNTs/Chits nanocomposite onto an indium-tin oxide (ITO) electrode. Mo-doped Mn3O4 (MMO) synthesized sol–gel method and the presence molybdenum improved its properties. The MMO/MWCNTs/Chits could accelerate electron transfer rate enlarge surface area to capture a large number Carcinoembryonic Antigen (CEA). factors influencing performance were investigated, such as incubation time, temperature pH. Under optimal conditions, detect CEA linear range from 0.1ng⋅mL−1 125ng⋅mL−1 with detection limit 4.9pg⋅mL−1 (S∕N=3). In addition, it exhibited high sensitivity acceptable stability on promising immobilization platform signal amplification, which be extended other labeled recognition systems. This may provide potential applications clinical diagnosis.
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