Studies on the neutralization of herpes simplex virus: III. Mechanism of the antibody-potentiating action of complement
作者： Kamesaburo Yoshino , Sadako Taniguchi
DOI: 10.1016/0042-6822(65)90026-7
关键词: Antibody 、 Sensitization 、 Virology 、 Complement (complexity) 、 Herpes virus 、 Mechanism (biology) 、 Neutralization 、 Virus 、 Herpes simplex virus 、 Biology
摘要: Abstract The mechanism of the antibody-potentiating action complement was investigated. In neutralization herpes virus by immune serum, formation virus-antibody complexes which are not necessarily neutral precedes viral inactivation. case early serum containing complement-requiring neutralizing (CRN) antibody, interval between binding and inactivation is very long, to shorten this interval. virus-CRN antibody binding, or sensitization CRN as well quicker at 37° than 4°. complex formed in absence easily dissociable simple dilution, nor other means such sonic vibration; has no blocking effect against hyperimmune antibody; remains sensitive during an stage adsorption cells.
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