作者: Chengjun Kang , Lin Yu , Guoqiang Cai , Liqun Wang , Hongliang Jiang
DOI: 10.1002/POLA.24798
关键词: Micelle 、 Copolymer 、 Radical polymerization 、 Ethylene glycol 、 Polymer chemistry 、 Nanocarriers 、 Methacrylate 、 Succinylation 、 Chemistry 、 Cationic polymerization
摘要: A novel type of well-defined graft copolymer, succinylated chitosan-O-poly(oligo(ethylene glycol)methacrylate) (SC-POEGMA), was developed for pH-reversible poly(ethylene glyocol) (PEG) shielding cationic nanocarriers. Chitosan-O-POEGMA (CS-POEGMA) first synthesized via single electron transfer-living radical polymerization oligo(ethylene glyol) methacrylate (OEGMA) using O-brominated chitosan (CS-Br) as a macromolecular initiator and Cu(I)Br/1,1,4,7,10,10-hexamethyltriethylenetetramine catalyst. The subsequent succinylation the backbone gave titled copolymers. content POEGMA in CS-POEGMA could be widely modulated by varying degree bromination feed ratio OEGMA to CS-Br, without compromising amino density backbone. hierarchical assembly between SC-POEGMA trimethylated chitosan-O-poly(e-caprolactone) (TMC-PCL) micelles further studied. At pH 7.4, stoichiometric interactions SC TMC segments form polyampholyte–polyelectrolyte complexes led formation PEG-shielded micelles. hierarchially assembled disassembled into pristine TMC-PCL micelles, when medium below certain (pHφ). By SC-POEGMA, pHφ value facilely from 6.5 3.5 meet needs specific biomedical applications. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Chem,